Drug American Dental Association

Question: Discuss about theDrugfor American Dental Association. Answer: Celecoxib Molecular formula is C17H14F3N3O2S (1). It can 1 hydrogen bond and accepts 7 H2 Rotatable bond count is 3 and covalently-bonded unit count is 1 (1). Celecoxib selectively inhibits cyclo-oxygenase-2 activity (1). Black, tarry or bloody stools, abdominal pain, chest, left arm or jaw pain, vomit that looks like coffee grounds, shortness of breath, weakness and unusual sweating are side effects (2). Etoricoxib Molecular formula is C18H15CIN2O2S (1). It has no hydrogen bond donor but accepts 4 hydrogen bonds. Rotatable bond count is 3 and covalently-bonded unit count is 1 (1). Etoricoxib is a COX-2 selective inhibitor (1). Indigestion, abdominal pain, constipation, weakness, diarrhoea, high BP, swelling and flue like symptoms are common side effects (2). Meloxicam Molecular formula is C14H13N3O4S2 (1). Hydrogen bond donor and acceptor counts are 2 and 7 respectively. Rotatable bond count is 2 and covalently-bonded unit count is 1 (1). Meloxicam preferentially inhibits the activity of COX-II (1). Chest pain, shortness of breath, weakness, slurred speech, swelling or rapid weight gain, problems with balance and vision, black, bloody or tarry stools and vomit that looks like coffee grounds or coughing up blood are some serious side effects (2). These drugs has some common side effects as their composition is nearly same. Swelling can occur due to allergic interactions. The most significant renal side effect of these non-steroidal anti-inflammatory drugs is analgesic nephropathy. The potential mechanism for analgesic nephropathy is the inhibition of renal prostaglandin synthesis. They have very few different side effects because of their slightly dissimilar compositions. References The PubChem Project [Internet]. Pubchem.ncbi.nlm.nih.gov. 2016 Aminoshariae A, Kulild JC, Donaldson M. Short-term use of nonsteroidal anti-inflammatory drugs and adverse effects: An updated systematic review. The Journal of the American Dental Association. 2016 Feb 29; 147(2):98-110.